Welcome to a webinar with Hanna Barriga, Karolinska Institute (Sweden) on biophysical analysis of nanoparticles for drug delivery!
This event is part of the Biophysics of Drug Delivery webinar series, organised by working group 4 of the IPDD theme.
When: Friday 8 March, 13:00 - 14:00 CET
Where: Please note that this is a webinar. Registered participants (online-only) will receive a zoom-link the same day as the event and with the registration confirmation.
Title: Biophysical analysis of nanoparticles for drug delivery – combining bulk and single particle techniques
Speaker: Hanna M.G. Barriga, Department of Medical Biochemistry and Biophysics at Karolinska Institute, Stockholm, Sweden
Abstract
Tuning the physicochemical properties of nanoparticles to engineer the nanoparticle surface and/or payload is the first step towards engineering precision nanomedicines for therapeutic applications. Despite the clinical success of nanoparticles, particularly lipid nanoparticles (LNPs), there are still key challenges which are creating a bottleneck for translation to the clinic. A key barrier to rational design is the ability to relate nanoparticle structure to performance. An additional complexity can also be the existence of populations of particles within a single formulation.
Our studies have shown that several factors can impact the structure of nanoparticles including formulation methods, composition, payload and surface labelling. By combining small angle scattering (SAXS / SANS) to measure the average structure of nanoparticle formulations together with single nanoparticle analysis (fluorescence / Raman (SPARTAÒ)) we are aiming to map structure and function relationships in nanoparticle formulations to advance our understanding of existing pharmaceuticals and develop the next generation of nanomedicines.
References
1) H.M.G. Barriga*, I.J. Pence*, M.N. Holme, J.J. Doutch, J. Penders, V. Nele, M.R. Thomas, M. Carroni, M.M. Stevens, Dynamic degradation of bioactive lipid nanoparticles by phospholipase D, Advanced Materials 2022, 34 (26), https://doi.org/10.1002/adma.202200839
2) T. Sych, J. Schlegel, H.M.G Barriga, M. Ojansivu, L. Hanke, F. Weber, R. Beklem Bostancioglu, K. Ezzat, H. Stangl, B. Plochberger, J. Laurencikiene, S. El Andaloussi, D. Fürth, M.M. Stevens, E. Sezgin, High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler, Nature Biotechnology, 2023, doi.org/10.1038/s41587-023-01825-5
3) C. Saunders, J.E.J. Foote, J.P. Wojciechowski, A. Cammack, S.V. Pedersen, J.J. Doutch, H.M.G. Barriga, M.N. Holme, J. Penders, M. Chami, A. Najer*, and M.M. Stevens*, Precise analytical description of population heterogeneity in vesicle-based nanomedicines using high throughput, single particle Raman analysis, ACS Nano, 2023, 17(12), 11713-11728, https://doi.org/10.1021/acsnano.3c02452
Bio
Hanna Barriga is a Research Specialist and Project Leader in the Department of Medical Biophysics and Biochemistry at Karolinska Institutet in the group of Prof. Molly Stevens. She received her PhD in Chemical Biology of Health and Disease from Imperial College London from the Department of Chemistry and moved to Sweden in 2016 with a Marie Skłodowska-Curie fellowship. Recently she was awarded the VR starting grant and ERC starting grant. Her research centers around using nanotechnology to solve biological challenges. This multidisciplinary approach is focused on advancing our understanding of the biophysics of lipids and nanoparticles in biological processes to accelerate the development of the next generation of engineered nanomedicines.
Contact: Please contact josefin.martell@linxs.lu.se for any practical questions.
During our events we sometimes take photographs and short film clips to profile our activities. Please let us know if you don’t want to be in any photos/films before we start the event. Some webinars are recorded to be used for educational purposes in the LINXS website.
By registering to our events you give your permission to LINXS, according to the General Data Protection Regulation (GDPR), to register your name and e-mail address to be used for the sole purpose of distributing newsletters and communications on LINXS activities.