Sign up for a 2-day mini-symposium on neutron diffraction in drug discovery, design and formulation (7-8 May), followed by an afternoon tour at European Spallation Source in Lund (8 May)!
Title: Neutron scattering in drug discovery, design, and formulation
When: 7–8 May, 2024, including buffet dinner at LINXS (7/5) and a visit to European Spallation Source (8/5)
Where: Workshop room on the 5th floor of LINXS (Scheelevägen 19, Lund) or online via Zoom. Physical participation is encouraged!
Fees and registration information:
Please indicate in the registration if you would like to join the dinner in the evening and the guided tour at ESS.
Physical participation: 700 SEK
Online participation: 350 SEK
EXTENDED DEADLINE! Please note that the registration deadline for the tour at ESS is 2/5.
Abstracts: There will be an opportunity to submit an abstract for a contributed talk. If you wish to have a talk, please send your abstract to raminta.venskutonyte@med.lu.se after completing the registration.
Walking Tour at European Spallation Source: Please note that there is a limited number of spots available for a walking tour of the experimental halls and deuteration labs. All those interested need to register by 2/5. Participants need to bring a picture ID for security purposes and also wear long trousers and closed shoes since we will be entering an active construction site.
Invited speakers
Program
May 7
11:00–13:00 Lunch and registration
13:00–13:10 Welcome and introduction
13:10–13:50 “Investigating structure and performance in lipid nanocarriers”, Hanna Barriga, Karolinska Institute, Stockholm
13:50–14:20 "Update on the Large-Scale Structures Instruments at ESS”, Thomas Arnold, European Spallation Source, Sweden
14:20–15:00 "Studies of hydrogen bonding in galectin-3 using neutron crystallography can aid drug design", Derek Logan, Lund University, Sweden
15:00–15:20 Coffee break
15:20–15:50 “DEMAX: the deuteration and crystallization support platform at ESS”, Zoë Fisher, European Spallation Source, Sweden
15:50–16:30 “Interactions at the lipid-aqueous interface – a key factor for drug delivery using lipid nanoparticles”, Tommy Nylander, Lund University
16:30–17:10 “The catalytic mechanism of the SARS CoV 2 Macrodomain and how to inhibit it”, James Fraser (via Zoom), UCSF School of Pharmacy, USA
17:30– Mingle followed by a buffet dinner at LINXS
May 8
08:45–09:15 Arrival and coffee/buns
09:15–09:55 “Structural investigation of lipid nanoparticle is key to improve mRNA delivery“, Federica Sebastiani, University of Copenhagen, Denmark
09:55–10:35 “A new view into the mechanism of apoptosis-regulating Bcl-2 proteins in mitochondrial membrane mimics using neutron reflection”, Hanna Wacklin-Knecht, European Spallation Source, Sweden
10:35–10:50 Coffee break
10:50–11:30 “How deep is your drug-depth-resolved drug interactions with lipid bilayers using neutrons”, Nicolo Paracini (via Zoom), Institut Laue-Langevin, France
11:30–12:00 Contributed talk
12:00–12:10 Final remarks and practicalities for the ESS visit
12:10–13:00 Lunch at LINXS
Travel to ESS
13:30–15:00 Safety instructions and tour at ESS
15:00–16:00 Coffee and Q&A
Organisers
The main organiser of the event is Raminta Venskutonyte raminta.venskutonyte@med.lu.se
For practical questions about the workshop, please contact josefin.martell@linxs.lu.se
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