Join us for a scientific workshop exploring analytical modelling approaches for lipid nanoparticles and their applications in research at the European Spallation Source (ESS).
When: 17–18 November 2026 (lunch-to-lunch)
Where: LINXS, The Loop, (Rydbergs torg 4, 224 84, Lund)
Organisers: Federica Sebastiani (UCPH/LU), Jan Skov Pedersen (AU), Sylvain Prevost (ILL)
The event is part of the LINXS theme “Soft Matter in Life” (SMILE), and a satellite following the ESS-ILL 2026 User Meeting.
About
This workshop will explore analytical modelling of lipid nanoparticles (LNPs), focusing on small-angle scattering (SAS), molecular dynamics (MD) simulations, experimental design and data analysis to improve the structural characterisation of LNPs.
Programme
Day 1: 17 November
12:00–12:35 Registration and lunch
12:35–12:40 Welcome and introduction — Organisers
12:40–13:25 Analytical Calculations of Small-Angle Scattering for Simplified Models of Lipid Nanoparticles
Jan Skov Pedersen, Aarhus University
13:25–14:10 Lipid nanoparticles prepared in a one-step process at physiological pH: structural analysis combining Cryo-TEM, SAXS and contrast-variation SANS
Kevin Roger, Chemical Engineering Center of Toulouse, France
14:10–14:55 (Title TBA)
Vladimir Rosenov Koynarev
14:55–15:25 Coffee break
15:25–16:10 Towards predicting small angle scattering of lipid nanoparticles utilising atomistic models generated using the Shapespyer toolchain
Hanna Barriga, KTH Royal Institute of Technology
16:10–16:55 Quantitative analysis of AuNP clustering on hybrid bilayers from the LNP SAXS data using CREASE
Rohan S. Adhikari, University of Delaware, USA
Day 2: 18 November
8:30–9:15 State of the Art & Modelling Bottlenecks
9:15–10:00 Formation Pathways, Processing & Stability
10:00–10:30 Coffee break
10:30–11:00 Post-Injection Fate & In-Use Perturbations
11:00–12:30 Implementation in Analytical SAS Models
12:30–13:00 Lunch
Contact: Please contact josefin.martell@linxs.lu.se for practical questions
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