When: 8 October, 14:00–15.00 CET
Where: Digital participation via Zoom
Speaker: Dr. Kevin Roger, Chemical Engineering Center of Toulouse, France
Abstract
Lipid nanoparticles have become essential carriers for polynucleotides such as mRNA, yet their internal organization remains difficult to establish. This difficulty is not only methodological: many formulations are likely to contain several colloidal subpopulations, making ensemble-averaged measurements intrinsically ambiguous and complicating comparisons across studies. In this webinar, I will present a formulation approach that produces a structurally homogeneous population of lipid nanoparticles, providing a well-defined system for quantitative analysis. I will show how combining small-angle X-ray and neutron scattering with cryogenic transmission electron microscopy makes it possible to reconcile information obtained across different length scales and contrasts. Contrast-variation experiments further allow the respective locations of the nanoparticle components to be constrained. Together, these complementary measurements provide a detailed picture of particle morphology and internal organization, while illustrating how reducing population heterogeneity can simplify the interpretation of complex soft-matter structures.
Biography
Dr Kevin Roger is a physical chemist working at the interface with chemical engineering. His research examines how intermolecular interactions, transport and processing history combine to determine the mesoscopic structure and macroscopic properties of complex fluids. He studies these questions across three main classes of non-equilibrium processes: drying, emulsification and nanoprecipitation. By moving between fundamental physical-chemistry questions and formulation or process challenges, his work connects mechanistic understanding with applications in academic and industrial contexts. He is a CNRS researcher at the Chemical Engineering Center of Toulouse, France, and an editor for JCIS Open.
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